2017-01-16 · gp130 Antibody (E-8) is a high quality monoclonal gp130 antibody (also designated IL6ST antibody, interleukin 6 signal transducer antibody, or CD130 antibody) suitable for the detection of the gp130 protein of mouse, rat and human origin. gp130 Antibody (E-8) is available as both the non-conjugated anti-gp130 antibody form, as well as multiple conjugated forms of anti-gp130 antibody, including

Knockout Tested Rabbit recombinant monoclonal CD130 (gp130) antibody [ EPR21732]. Validated in WB, ELISA and tested in Human, Recombinant fragment.

gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. Glycoprotein gp130 has a molecular mass of 130–150 kDa; gp130 has the alternative names IL-6Rβ, CD130, and IL-6 signal transducer. The molecular cloning of human gp130cDNA was reported in 1990 (database accession, M57230). Macrophage recruitment is essential for heart regeneration through the secretion of OSM, which promotes cardiomyocyte proliferation. As the coreceptor of OSM, gp130 activation is sufficient to promote cardiomyocyte proliferation by activating Yap through Src during heart regeneration. gp130 is a pot … One typical example is a group of receptor systems for interleukin-6 (IL-6) and related cytokines that share gp130 as a signal transducer.

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Both of these receptor subunits can be shed from the cell surface and regulate distinct mechanisms of gp130-mediated signaling. Lamertz et al . engineered a reductionist system 2000-02-08 · The gp130 gene comprises 17 exons and 16 introns. The positions of the exon-intron boundaries show good correlation to the functional/homology regions of gp130. Exons 3-17 code for the gp130 protein, and each subdomain of the receptor is encoded by a set of exons. Cotransfection of gp130 cDNA increased the number of high-affinity binding sites, but gp130 did not directly bind IL6 (147620) or several other cytokines. Mouse IL3 (147740)-dependent pre-B cells proliferated when cultured with IL6 plus soluble IL6RA only following transfection with human gp130.

The molecular cloning of human gp130cDNA was reported in 1990 (database accession, M57230).

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and. STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002; 8:1089-1097.

Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. Interactions IL6ST (Interleukin 6 Cytokine Family Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Hyper-Ige Recurrent Infection Syndrome 4, Autosomal Recessive and Stuve-Wiedemann Syndrome.Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Physiological and Pathological Hypertrophy of the Heart. GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3).

View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR010457, IgC2-like_lig-bd IPR015321, TypeI_recpt_CBD: Pfam i: View protein in Pfam PF00041, fn3, 2 hits PF09240, IL6Ra-bind, 1 hit PF06328, Lep_receptor_Ig, 1 hit: SMART i: View

Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. Interactions IL6ST (Interleukin 6 Cytokine Family Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Hyper-Ige Recurrent Infection Syndrome 4, Autosomal Recessive and Stuve-Wiedemann Syndrome.Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Physiological and Pathological Hypertrophy of the Heart. GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003529, Hematopoietin_rcpt_Gp130_CS IPR013783, Ig-like_fold IPR010457, IgC2-like_lig-bd IPR015321, TypeI_recpt_CBD: Pfam i: View protein in Pfam PF00041, fn3, 2 hits PF09240, IL6Ra-bind, 1 hit PF06328, Lep_receptor_Ig, 1 hit: SMART i: View Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130.

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses Signal transduction in response to interleukin-6 (IL-6) requires binding of the cytokine to its receptor (IL-6R) and subsequent homodimerization of the signal transducer gp130. GP130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines (1-3). The binding of a ligand to its receptor induces the dimerization of GP130, leading to activation of the Jak tyrosine kinase and to tyrosine phosphorylation of GP130. INTRODUCTION: Ubiquitously expressed in the human body, glycoprotein 130 (gp130) is a shared subunit of receptor complexes for at least nine cytokines (IL-6, OSM, LIF, IL-11, CNTF, CLC, IL-27, CT-1, and NP) that mediate highly diverse biological processes.
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CLC: CLF-1: CNTFRa komplex därefter rekryterar gp130 / LIFRp som förmedlar trans signalering via Janus kinas / signalomvandlare och  av MG till startsidan Sök — Defective glycosylation leads to defective gp130-dependent STAT3 signaling in PGM3-deficient patients. J Allergy Clin Immunol 2018: doi:  Titel , JLM BW-GP130 20 - Grupporträtt. Bildtext . Elsa Widén-Jonsson, blind sångerska från Östersund och Rut Lindberg för Året  Denna familj delas i tre subfamiljer, γ, β samt gp130.

4 000 €. Glykoprotein 130 (även känt som gp130 , IL6ST , IL6-beta eller CD130 ) är ett transmembranprotein som är den grundande medlemmen i  3 gp130 in TNF-a expression sgp130 concentrations in the culture supernatants of PMN Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor  individer med allvarlig depression. Fas 4-studie om effekten av partiell sömnbrist på kognition och IL-6-gp130-systemet hos individer med allvarlig depression  IL-6 / Glycoprotein130 (GP130) roll i NASH är oklart. Blockering av IL-6 / GP130-signalering med MR16-1 förbättrad MCD-dietinducerad hepatisk steatos, men  Uppsats: Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130.
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Cotransfection of gp130 cDNA increased the number of high-affinity binding sites, but gp130 did not directly bind IL6 (147620) or several other cytokines. Mouse IL3 (147740)-dependent pre-B cells proliferated when cultured with IL6 plus soluble IL6RA only following transfection with human gp130.

Värd, Rabbit. Original Derbi Kühlerschlauch MULHACEN GP130 (00N03800021) Kühlerschlauch MULHACEN GP130.